J. A. Moler Cuiral, F. Plo, N. Flournoy
In the early phases of a clinical trial, the main statistical target is to estimate percentiles in response variables in order to control toxicity and efficiency of new drugs or, even, new medical procedures. In this work we present tools to study the performance of adaptive designs in phases I or II of clinical trials. The combined study of inferential and ethical criteria is also considered. Finally, these tools are used in a simulation study that evaluates the performance of some relevant adaptive procedures.
Palabras clave / Keywords: adaptive designs, optimal designs
Programado
Sesión GT07-1 Diseño de Experimentos: Advances in Experimental Design (OED-1). Organizadores: Víctor Casero-Alonso y Jesús López-Fidalgo
30 de mayo de 2018 10:50
Sala 6
