V. Casero-Alonso, A. Pepelyshev, W. K. Wong
Hormesis has been widely observed and debated in a variety of context in biomedicine and toxicological sciences. Detecting its presence can be an important problem with wide ranging implications. However, there is little work on constructing an efficient experiment to detect its existence or estimate the threshold dose. We use optimal design theory to develop a variety of optimal designs to detect hormesis, estimate the threshold dose and the zero-equivalent point (ZEP) for commonly used models in toxicology and risk assessment. To facilitate the use of more efficient designs to detect hormesis, estimate the threshold dose and estimate the ZEP in practice, we implement computer algorithms and create a user-friendly web site to help the biomedical researcher generate different types of optimal designs. The online tool facilitates the user to evaluate robustness properties of a selected design to various model assumptions and compare designs before implementation.
Palabras clave / Keywords: approximate design, D-efficiency, risk assessment, toxicology, ZEP dose
Programado
Sesión GT07-2 Diseño de Experimentos: Diseño Óptimo de Experimentos (OED-2). Organizador: Mariano Amo-Salas
29 de mayo de 2018 12:20
Sala 1
